Complex Conditions Mitral Regurgitation - Severe Lesson Waveform Anatomy play pause Table of Contents 1Mitral Regurgitation - Severe 2Tricuspid Regurgitation - Severe 3Mitral Stenosis Severe and Regurgitation Mild - Rheumatic Origin 4Aortic Stenosis Moderate and Regurgitation Mild - Rheumatic Origin 5Mitral Regurgitation and Aortic Regurgitation 6Acute Pericarditis Practice Quiz This video is an animation of Mitral Regurgitation - Severe A#28 (lesson# 1) within course number 1. This is an example of severe mitral regurgitation which is caused by degeneration of the mitral valve leaflets.The first heart sound is normal. The second heart sound is widely split.Following the second heart sound there is a third heart sound gallop.There is a loud, rectangular, pansystolic murmur. There is a brief, rumbling, diamond-shaped diastolic murmur immediately following the third heart sound.In the anatomy tab you can see the enlarged left atrium and left ventricle. You can see the turbulent blood flow from the left ventricle into the left atrium. This is the systolic murmur. You can see the brief turbulent blood flow from the left atrium to the left ventricle in diastole. This is caused by too much blood in the left atrium which forces blood back into the ventricle during diastole producing the flow rumble.